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Mycophenolic acid

产品号 S2487 公司名称 Selleck Chemicals
CAS号 24280-93-1 公司网站 http://www.selleckchem.com
分子式 C17H20O6 电 话 (877) 796-6397
分子量 320.3371 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 897

产品价格信息

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产品别名

标题
Mycophenolic acid
IUPAC标准名
(4E)-6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydro-2-benzofuran-5-yl)-4-methylhex-4-enoic acid
IUPAC传统名
mycophenolic acid
别名
Mycophenolate

产品登记号

CAS号 24280-93-1

产品性质

成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Immunology
Biological Activity:
Mycophenolic acid (mycophenolate) is an immunosuppressant agent used to prevent rejection in organ transplantation. Mycophenolic acid (mycophenolate) is derived from the fungus Penicillium stoloniferum. Mycophenolate mofetil is metabolised in the liver to the active moiety mycophenolic acid. Mycophenolic acid (mycophenolate) inhibits inosine monophosphate dehydrogenase, the enzyme that controls the rate of synthesis of guanine monophosphate in the de novo pathway of purine synthesis used in the proliferation of B and T lymphocytes. [1] Mycophenolic acid (mycophenolate) is potent and can be used in place of the older anti-proliferative azathioprine. Mycophenolic acid (mycophenolate) is usually used as part of a three-compound regimen of immunosuppressants, also including a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. [2]

参考文献

  • Ransom JT et al. Ther Drug Monit. 1995 Dec;17(6)