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Fleroxacin

产品号 S2469 公司名称 Selleck Chemicals
CAS号 79660-72-3 公司网站 http://www.selleckchem.com
分子式 C17H18F3N3O3 电 话 (877) 796-6397
分子量 369.3383296 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 73035

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产品别名

标题
Fleroxacin
IUPAC标准名
6,8-difluoro-1-(2-fluoroethyl)-7-(4-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
IUPAC传统名
fleroxacin
别名
Quinodis
Megalocin

产品登记号

CAS号 79660-72-3

产品性质

成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Infection
Biological Activity:
Fleroxacin(Quinodis) is a new broad-spectrum fluoroquinolone. In a study, fleroxacin significantly inhibited cell proliferation in a dose- and time-dependent manner at concentrations of 50-800 microg/mL for 12, 24, and 48 hours. The inhibitory effects of fleroxacin combined with 5-FU appeared synergistic using normalized isobologram and combination index analysis. In vivo, no significant changes in bladder tumor frequency were noted between the control and fleroxacin and 5-FU groups. Significant inhibition of tumor frequency was observed only when fleroxacin was administered with 5-FU.Fleroxacin combined with 5-FU inhibited the proliferation of bladder tumor cell lines both in vitro and in vivo. This combination therapy might be applicable in clinical settings. [1]

参考文献

  • Nishikawa T et al. Urology. 2009 Dec;74(6):1370-6