Clozapine

• 产品号: S2459
• CAS号: 5786-21-0
• 分子式: C18H19ClN4
• 分子量: 326.82326
• 保 存: -20°C

产品别名

• 标题: Clozapine
• IUPAC标准名: 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
• IUPAC传统名: 6-chloro-10-(4-methylpiperazin-1-yl)-2,9-diazatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaene
• 别名: Leponex; Fazaclo; Azaleptin; Clozaril

产品登记号

• CAS号: 5786-21-0

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Neurological Disease
Biological Activity:
Clozapine (Clozaril) is a potent 5-HT1C receptor antagonist with an IC50 of 110 nM for 5-HT-stimulated phosphoinositide hydrolysis. It is an antipsychotic medication used in the treatment of schizophrenia, and is also used off-label in the treatment of bipolar disorder. Clozapine is classified as an atypical antipsychotic drug because its profile of binding to serotonergic as well as dopamine receptors; its effects on various dopamine mediated behaviors also differ from those exhibited by more typical antipsychotics. [1][2]

参考文献

• Kuoppam?ki M et al. Eur J Pharmacol. 1993 Apr 15