Sophocarpine

• 产品号: S2405
• CAS号: 6483-15-4
• 分子式: C15H22N2O
• 分子量: 246.34798
• 保 存: -20°C

产品别名

• 标题: Sophocarpine
• IUPAC标准名: (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadec-4-en-6-one
• IUPAC传统名: (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.0^{2,7}.0^{13,17}]heptadec-4-en-6-one

产品登记号

• CAS号: 6483-15-4

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cardiovascular Disease
Biological Activity:
Sophocarpine is a human ether-à-go-go-related gene (HERG) inhibitor with an IC(50) of about 0.2 mM. Sophocarpine (SC) were examined on stably expressed HERG channels in human embryonic kidney (HEK293) cells using a whole-cell patch clamp technique, Western blot analysis and immunofluorescence experiments. Sophocarpine inhibited HERG channels in a concentration-dependent manner. Sophocarpine significantly accelerated channel inactivation, recovery from inactivation and onset of inactivation. In addition, it had no effect on channel activation and deactivation. Based on Western blot and immunofluorescence results, SC had no significant effect on the expression of HERG protein. [1][2]

参考文献

• Zhao XL et al. Biol Pharm Bull. 2008 Apr;31(4):627-32.