Tetrandrine(Fanchinine)

• 产品号: S2403
• CAS号: 518-34-3
• 分子式: C38H42N2O6
• 分子量: 622.74988
• 保 存: -20°C

产品别名

• 标题: Tetrandrine(Fanchinine)
• IUPAC标准名: (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{14,18}.0^{27,31}.0^{22,33}]hexatriaconta-3,5,8(34),9,11,18,20,22(33),24,26,31,35-dodecaene
• IUPAC传统名: (1S,14S)-9,20,21,25-tetramethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.2^{3,6}.1^{8,12}.1^{14,18}.0^{27,31}.0^{22,33}]hexatriaconta-3,5,8(34),9,11,18,20,22(33),24,26,31,35-dodecaene
• 别名: S-(+)-Tetrandrine; S; NSC 77037; Hanfangchin A; Fanchinine

产品登记号

• CAS号: 518-34-3

产品性质

• 作用靶点: calcium channel
• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cancer
Biological Activity:
Tetrandrine (Fanchinine; Hanfangchin A) is a calcium channel blocker with an IC50 of 38.23± 25.77 μM. Tetrandrine (Fanchinine; Hanfangchin A) has anti-inflammatory, immunologic and antiallergenic effects. Tetrandrine (Fanchinine; Hanfangchin A) inhibits the degranulation of mast cells. Tetrandrinehas a "Quinidine like" anti-arrhythmic effect. Tetrandrine (Fanchinine; Hanfangchin A) has been isolated from Stephania tetandra and other Chinese and Japanese Herbs. Tetrandrine (Fanchinine; Hanfangchin A) increased populations of both apoptotic sub-G1 and G1 phase. Tetrandrine-induced growth inhibition was associated with induction of Cdk inhibitor p21, inhibition of cyclin D1 and activation of caspase-3. Tetrandrine (Fanchinine; Hanfangchin A) also affected the expression patterns of cytoskeletons including distribution of F-actin and expression level of microtubule. [1][2][3]References on Tetrandrine(Fanchinine)[2] Int J Oncol., 2002 Dec, 21(6):1239-44.[3] http://en.wikipedia.org/wiki/Tetrandrine, , [1] Cancer Letters, 2008, 268:166–175

参考文献

• Lee JH et al. Int J Oncol. 2002 Dec;21(6):1239-44.