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Rhein(Monorhein)

产品号 S2400 公司名称 Selleck Chemicals
CAS号 478-43-3 公司网站 http://www.selleckchem.com
分子式 C15H8O6 电 话 (877) 796-6397
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产品别名

标题
Rhein(Monorhein)
IUPAC标准名
4,5-dihydroxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid
IUPAC传统名
rhein
别名
NSC 38629
Rheinic acid
Rheic acid
Monorhein
Rhubarb yellow

产品登记号

CAS号 478-43-3

产品性质

成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Immunology
Biological Activity:
Rhein(Monorhein; NSC 38629; Rheic acid; Rheinic acid) is a constituent of rhubarb which was isolated from the fresh rhizome of Rheum coreanum Nakai. The WTK1 cells were treated by rhein of different concentrations (20, 40, 80, 120 μg/ml) and then the comet assay, in vitro micronucleus test and TK gene mutation assay were conducted simultaneously. The solvent control and positive control (mthylmethane sulfonate, MMS) groups were included in the study. Positive results were found at the concentrations of 120 μg/ml and 80 μg/ml of emodin in comet assay and tk gene mutation analysis. High dose of rhein (120 μg/ml) also showed weak mutagenicity in TK gene mutation analysis. In a study, compared with the db/db control group, the fasting glucose concentration was significantly decreased in the rhein treatment group. The first-phase insulin secretory function was impaired significantly in db/db mice, while the first-phase insulin secretory peak was obvious in the rhein treatment mice. Rhein treatment significantly improved glucose tolerance, restored the first-phase insulin secretion and protected the islets function. [1]

参考文献

  • Du H et al. Zhongguo Zhong Yao Za Zhi. 2010 Oct;35(20):2764-7.