Lappaconite Hydrobromide

• 产品号: S2387
• CAS号: 97792-45-5
• 分子式: C32H45BrN2O8
• 分子量: 665.6123
• 保 存: -20°C

产品别名

• 标题: Lappaconite Hydrobromide
• IUPAC标准名: (1S,2S,3S,4S,5R,6S,8S,9S,13S,16S,17S)-11-ethyl-3,8-dihydroxy-4,6,16-trimethoxy-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-13-yl 2-acetamidobenzoate hydrobromide
• IUPAC传统名: (1S,2S,3S,4S,5R,6S,8S,9S,13S,16S,17S)-11-ethyl-3,8-dihydroxy-4,6,16-trimethoxy-11-azahexacyclo[7.7.2.1^{2,5}.0^{1,10}.0^{3,8}.0^{13,17}]nonadecan-13-yl 2-acetamidobenzoate hydrobromide

产品登记号

• CAS号: 97792-45-5

产品性质

• 成盐信息: Hydrobromide
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Inflammation
Biological Activity:
Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg•L-1 to 40 mg•L-1,the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level.The inhibitors of P-glycoprotein had obvious effects on the absorption in small intestines.Sodium caprate was the best enhancer that did not cause significant changes in the morphology of the intestinal membrane after intestinal administration as compared with other absorption enhancers. [1][2] 

参考文献

• Wang YZ et al. J Tradit Chin Med. 2009 Jun;29(2):141-5.