氟化氢吡啶络合物

• 产品号: L17117
• CAS号: 62778-11-4
• 分子式: C5H6FN
• 分子量: 99.1062432
• 纯 度: ca 70% HF

产品别名

• 标题: Hydrogen fluoride pyridine complex
• IUPAC标准名: pyridine hydrofluoride
• IUPAC传统名: pyridine hydrofluoride
• 别名: Pyridinium poly(hydrogen fluoride); Olah's Reagent

产品登记号

• MDL号: MFCD00012436
• 默克索引号: 146821
• Beilstein号: 4750151
• CAS号: 62778-11-4

产品性质

• 纯度: ca 70% HF
• 沸点: 50°C/1mm
• 密度: 1.100
• GHS危险声明: H300-H310-H330-H314-H318
• 欧盟危险性物质标志: 剧毒(Highly toxic) (T+)
• GHS警示性声明: P260-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P320-P330-P361-P405-P501A
• 危险公开号: 26/27/28-35
• 安全公开号: 26-28-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN1790
• 联合国危险货物包装类别(PG): I

参考文献

• Convenient form of anhydrous HF, showing increased reactivity in many reactions: J. Org. Chem., 44, 3872 (1979). Alkenes and alkynes undergo hydrofluorination; in the presence of NIS or NBS, iodo- or bromofluorination occurs: Synthesis, 779 (1973). Secondary and tertiary alcohols are converted to alkyl fluorides: Synthesis, 653 (1974). Diazotization of ɑ-amino acids in the presence of the reagent provides good yields of ɑ-fluoro acids: Synthesis, 654 (1974). Reaction with aryldiazonium salts or triazenes leads to aryl fluorides, providing a convenient alternative to the Balz-Schiemann reaction (see Tetrafluoroboric acid, L14037): J. Am. Chem. Soc., 97, 208 (1975); J. Chem. Soc., Chem. Commun., 914 (1979); Bull. Chem. Soc. Jpn., 63, 2058 (1990).
• In combination with nitrosonium tetrafluorborate, ketoximes are converted to gem-difluorides: Synlett, 425 (1994).
• For use in electrophilic electrochemical fluorination, see: J. Fluorine Chem., 83, 31 (1997).
• The reagent is also widely applied to the cleavage of a variety of silyl protecting groups including TBDMS, TES, TBDPS and TIPS: Synthesis, 453 (1986); J. Am .Chem. Soc., 112, 7001 (1990); for further discussion see: P. Kocienski, Protecting Groups, Thieme, Stuttgart (1994).