Research Area: Cancer
Biological Activity:
Apigenin is a potent CYP2C9 inhibitor with an IC50 of 23 pM. CYP2C9 is an enzyme responsible for the metabolism of many pharmaceutical compounds in the body. Apigenin is commonly recognised as to mediate at least part of the chemopreventive action of vegetables and fruits in the cancerous process. Recently it was shown that apigenin induces a process called autophagia (a kind of cellular dormancy) which may well explain it chemopreventive properties but at the same time induces resistance against chemotherapy. Apigenin is a flavone that is the aglycone of several glycosides. [1][2]References on Apigenin[1] http://en.wikipedia.org/wiki/Apigenin, , [2] Drug Metab Dispos., 2009 Mar, 37(3):629-34 |