4-Methylumbelliferone(4-MU)

• 产品号: S2256
• CAS号: 90-33-5
• 分子式: C10H8O3
• 分子量: 176.16872
• 保 存: -20°C

产品别名

• 标题: 4-Methylumbelliferone(4-MU)
• IUPAC标准名: 7-hydroxy-4-methyl-2H-chromen-2-one
• IUPAC传统名: 4-methylumbelliferone
• 别名: 4-MU

产品登记号

• CAS号: 90-33-5

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cancer
Biological Activity:
4-Methylumbelliferone(4-MU) is a hyaluronic acid (HA) synthesis inhibitor with an IC50 of 0.4 mM. 4-MU inhibited proliferation, motility, and invasion of DU145, PC3-ML, LNCaP, C4-2B, and/or LAPC-4 cells. At IC(50) for HA synthesis (0.4 mM), 4-MU induced >3-fold apoptosis in prostate cancer cells, which could be prevented by the addition of HA. The anticancer effects of 4-MU, an orally bioavailable and relatively nontoxic agent, are primarily mediated by inhibition of HA signaling. [1][2] 

参考文献

• Kultti A et al. Exp Cell Res. 2009 Jul 1;315(11):1914-23