PIK-293

• 产品号: S2207
• CAS号: 900185-01-5
• 分子式: C22H19N7O
• 分子量: 397.43256
• 保 存: -20°C

产品别名

• 标题: PIK-293
• IUPAC标准名: 2-({4-amino-1H-pyrazolo[3,4-d]pyrimidin-1-yl}methyl)-5-methyl-3-(2-methylphenyl)-3,4-dihydroquinazolin-4-one
• IUPAC传统名: 2-({4-aminopyrazolo[3,4-d]pyrimidin-1-yl}methyl)-5-methyl-3-(2-methylphenyl)quinazolin-4-one

产品登记号

• CAS号: 900185-01-5

产品性质

• 作用靶点: PI3K
• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area

• Description: Cancer

Biological Activity

• Description: PIK-293 is a PI3-K inhibitor for p110α, p110β, p110δ and p110γ with IC50 of 100 μM, 25 μM, 0.24 μM and 10 μM, respectively.
• Targets: p110α; p110β; p110δ; p110γ
• IC50: 100 μM; 25 μM; 0.24 μM; 10 μM ^[1]
• In Vitro: PIK-293 is a pyrazolopyrimidine analog of IC87114. PIK-293 is synthesized by replacing the adenine of IC87114 with the isosteric pyrazolopyrimidine. ^[1]

References

• References: [1] Knight ZA et al. Cell, 2006, 125(4), 733-747.

参考文献

• Knight ZA et al. Cell, 2006, 125(4), 733-747.