4,6-二苯基噻吩[3,4-d]-1,3-二氧-2-酮-5,5-二氧

• 产品号: L13513
• CAS号: 54714-11-3
• 分子式: C17H10O5S
• 分子量: 326.3233
• 纯 度: 97%

产品别名

• 标题: 4,6-Diphenylthieno[3,4-d]-1,3-dioxol-2-one 5,5-dioxide
• IUPAC标准名: diphenyl-2H-5λ^6-thieno[3,4-d][1,3]dioxole-2,5,5-trione
• IUPAC传统名: diphenyl-5λ^6-thieno[3,4-d][1,3]dioxole-2,5,5-trione
• 别名: TDO activated carbonate; Steglich's Reagent

产品登记号

• Beilstein号: 1396884
• EC号: 259-301-2
• MDL号: MFCD00040564
• CAS号: 54714-11-3

产品性质

• 纯度: 97%
• 熔点: 224-230°C
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 危险公开号: 36/37/38
• 安全公开号: 26-37
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否

参考文献

• Reagent for the formation of active esters for peptide coupling or esterification. In the presence of 1 equiv. of base, these enolize with formation of a deep red anion in which the enolate oxygen is well placed to facilitate aminolysis or alcoholysis: Angew. Chem. Int. Ed., 15, 444 (1976). Aminolysis occurs more rapidly in dichloromethane than in the more polar DMF. Progress of acylation can readily be followed by disappearance of the red color of the active ester, giving scope for the possibility of automatic monitoring of the reaction: J. Chem. Soc., Chem. Commun., 1870 (1987).
• Reacts with t-butanol and pyridine to give an activated reagent for the formation of Boc derivatives of amino acids which can then further react with the reagent to form active esters for peptide coupling: Angew. Chem. Int. Ed., 18, 307 (1979); Liebigs Ann. Chem., 437 (1988). For peptide reagents, see Appendix 6.