3-羟基丙腈

• 产品号: L12570
• CAS号: 109-78-4
• 分子式: C3H5NO
• 分子量: 71.0779
• 纯 度: 98%

产品别名

• 标题: 3-Hydroxypropionitrile
• IUPAC标准名: 3-hydroxypropanenitrile
• IUPAC传统名: ethylene cyanohydrin
• 别名: Ethylene cyanohydrin; 2-Cyanoethanol

产品登记号

• 默克索引号: 143794
• Beilstein号: 635773
• MDL号: MFCD00002826
• CAS号: 109-78-4
• EC号: 203-704-8

产品性质

• 纯度: 98%
• 沸点: 227-228°C
• 密度: 1.041
• 闪点: 128°C(262°F)
• 熔点: -46°C
• 折射率: 1.4250
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 危险公开号: 36/37/38
• RTECS编号: MU5250000
• 安全公开号: 26-37
• TSCA收录: 是

参考文献

• Protection of carboxylic acids as 2-cyanoethyl esters can be accomplished by DCC-DMAP coupling. The esters can be cleaved with TBAF in DMF-THF: Chem. Pharm. Bull., 42, 147 (1994), or Na₂S in methanol: Chem. Pharm. Bull., 42, 1579 (1994).
• Can also be used to protect the phosphate group, by condensation with 2,4,6-Triisopropylbenzenesulfonyl chloride, A11458: Chem. Pharm. Bull.,25, 2844 (1977), or DCC: J. Am. Chem. Soc., 83, 159 (1961). Cleavage can be effected with an amine: Tetrahedron Lett., 23, 5119 (1982), ammonia: J. Org. Chem., 59, 2482 (1994); Tetrahedron Lett., 35, 4311 (1994), or TBAF: Tetrahedron Lett., 1255 (1976).
• Precursor of 2-cyanoethyl 2,2,2-trichloroethyl phosphorochloridate, a reagent for the phosphorylation of nucleosides: Synthesis, 831 (1980); see 2,2,2-Trichloroethanol, L08163.