Pramipexole dihydrochloride monohy

• 产品号: S2011
• CAS号: 191217-81-9
• 分子式: C10H21Cl2N3OS
• 分子量: 302.26424
• 保 存: -20°C

产品别名

• 标题: Pramipexole dihydrochloride monohy
• IUPAC标准名: (6S)-6-N-propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride
• IUPAC传统名: pramipexole hydrate dihydrochloride
• 别名: Mirapexin; Mirapex; Sifrol

产品登记号

• CAS号: 191217-81-9

产品性质

• 成盐信息: Coordination Co
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Neurological Disease
Biological Activity:
Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM. It also possesses low/insignificant affinity (500-10,000 nM) for the 5-HT1A, 5-HT1B, 5-HT1D, and α2-adrenergic receptors. It has negligible affinity (>10,000 nM) for the D1, D5, 5-HT2, α1-adrenergic, β-adrenergic, H1, and mACh receptors. It is a non-ergoline dopamine agonist indicated for treating early-stage Parkinson’s disease (PD) and restless legs syndrome (RLS). [1][2][3]

参考文献

• http://en.wikipedia.org/wiki/Pramipexole