Tamoxifen Citrate

• 产品号: S1972
• CAS号: 54965-24-1
• 分子式: C32H37NO8
• 分子量: 563.63808
• 保 存: -20°C

产品别名

• 标题: Tamoxifen Citrate
• IUPAC标准名: (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine; 2-hydroxypropane-1,2,3-tricarboxylic acid
• IUPAC传统名: citro; tamoxifen
• 别名: Nolvadex; Valodex; Istubal

产品登记号

• CAS号: 54965-24-1

产品性质

• 成盐信息: Citrate
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Endocrinology
Biological Activity:
Tamoxifen Citrate (Nolvadex) is an estrogen receptor antagonist with an IC50 of 31 μM for the MCF-7 cells. In some tissues such as the endometrium, it behaves as an agonist, hence tamoxifen may be characterized as a mixed agonist/antagonist. It has been the standard endocrine (anti-estrogen) therapy for hormone-positive early breast cancer in pre-menopausal women, although aromatase inhibitors have been proposed. [1][2]References on Tamoxifen Citrate (Nolvadex)[] Journal of Steroid Biochemistry & Molecular Biology, 2003, 84 ：255–257

参考文献

• Seeger H et al. J Steroid Biochem Mol Biol. 2003