Fluvastatin Sodium

• 产品号: S1909
• CAS号: 93957-55-2
• 分子式: C24H25FNNaO4
• 分子量: 433.4477732
• 保 存: -20°C

产品别名

• 标题: Fluvastatin Sodium
• IUPAC标准名: sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoate
• IUPAC传统名: sodium (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropylindol-2-yl]-3,5-dihydroxyhept-6-enoate
• 别名: Vastin; Lescol; XU 62-320; Canef

产品登记号

• CAS号: 93957-55-2

产品性质

• 成盐信息: Sodium
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cardiovascular Disease
Biological Activity:
Fluvastatin sodium (Lescol) is an orally active, potent and competitive HMG-CoA reductase inhibitor with an IC50 of 70 nM for vascular smooth muscle proliferation in vitro. (IC50 = 40 -100 nM at human liver microsomes). It exhibits antihyperchole-sterolemic and antioxidant activity in vivo. Fluvastatin Sodium is used to reduce LDL-cholesterol, apolipoprotein B, and triglycerides, and to increase HDL-cholesterol, in the treatment of hyperlipidaemias, including hypercholesterolaemias and combined (mixed) hyperlipidaemia (type IIa or IIb hyperlipoproteinaemias). [1]

参考文献

• http://en.wikipedia.org/wiki/Fluvastatin