炔丙基溴

• 产品号: L10595
• CAS号: 106-96-7
• 分子式: C3H3Br
• 分子量: 118.95992
• 纯 度: 97%, 80% w/w in toluene

产品别名

• 标题: Propargyl bromide
• IUPAC标准名: 3-bromoprop-1-yne
• IUPAC传统名: 1-propyne, 3-bromo-
• 别名: 3-Bromo-1-propyne

产品登记号

• MDL号: MFCD00000241
• CAS号: 106-96-7
• EC号: 203-447-1
• Beilstein号: 605309

产品性质

• 纯度: 97%, 80% w/w in toluene
• 沸点: 88-90°C
• 密度: 1.335
• 闪点: 3°C(37°F)
• 熔点: -61°C
• 折射率: 1.4940
• GHS危险声明: H225-H301-H335-H336-H304-H361-H373-H314
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P210-P301+P310-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 11-25-34-37-48/20-63-65-67
• RTECS编号: UK4375000
• 安全公开号: 9-16-20-23-26-33-36/37/39-45-60
• 保存注意事项: Light Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN2924
• 联合国危险货物包装类别(PG): II

参考文献

• With Mg in ether, generates allenylmagnesium bromide which can be coupled with a further molecule of propargyl bromide to give the bis-allene 1,2,4,5-hexatetraene: Org. Synth. Coll., 7, 485 (1990). Diels-Alder reaction of the product with Dimethyl acetylenedicarboxylate, A11437 leads to a para-cyclophane.
• Barbier-type reaction with aldehydes in aqueous THF gives the secondary alcohols in moderate to good yields: Synth. Commun., 25, 2923 (1995); partial rearrangement to the allene could occur; cf Allyl bromide, A11766, for similar reactions. For reaction with aldehydes in the presence of Zn in THF, and transformation of the resulting secondary alcohols into pyruvate esters, see: J. Chem. Chem. Commun ., 1289 (1991).
• For conversion to dimethyl-2-propynylsulfonium bromide and condensation with 2,4-pentanedione and other active methylene compounds in a versatile, high-yield synthesis of substituted furans, see: J. Chem. Soc., Perkin 1, 65 (1973); Org. Synth. Coll ., 6, 31 (1988).
• For diastereoselective propargylation of ɑ -alkoxy aldehydes and application in the synthesis of oxygenated acyclic natural products, see: J. Org. Chem., 60, 3257 (1995).