Diclofenac

• 产品号: S1903
• CAS号: 15307-79-6
• 分子式: C14H10Cl2NNaO2
• 分子量: 318.13047
• 保 存: -20°C

产品别名

• 标题: Diclofenac; Diclofenac sodium
• IUPAC标准名: sodium 2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetate
• IUPAC传统名: sodium diclofenac(1-)
• 别名: Benfofen; Voltaren; Solaraze; Ecofenac

产品登记号

• CAS号: 15307-79-6

产品性质

• 作用靶点: COX
• 成盐信息: sodium salt
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: cancer
Biological Activity:
Diclofenac is a non-selective COX inhibitor with IC50 of 60 and 220 nM for ovine COX-1 and -2, respectively. It inhibits human COX-1 and -2 with IC50 values of 0.9-2.7 and 1.5-20 µM, respectively. It is thought that the primary mechanism responsible for its anti-inflammatory, antipyretic, and analgesic action is inhibition of prostaglandin synthesis by inhibition of cyclooxygenase (COX), and it appears to inhibit DNA synthesis. [1][2]

参考文献

• http://en.wikipedia.org/wiki/Diclofenac
• Patrignani P et al. J Physiol Pharmacol. 1997 Dec;48(4):623-31.