Mitoxantrone Hydrochloride

• 产品号: S1889
• CAS号: 70476-82-3
• 分子式: C22H30Cl2N4O6
• 分子量: 517.4028
• 保 存: -20°C

产品别名

• 标题: Mitoxantrone Hydrochloride
• IUPAC标准名: 1,4-dihydroxy-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-dihydroanthracene-9,10-dione dihydrochloride
• IUPAC传统名: mitoxantrone dihydrochloride
• 别名: Novantrone; NSC-310739

产品登记号

• CAS号: 70476-82-3

产品性质

• 作用靶点: DNA/RNA
• 成盐信息: Hydrochloride
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cancer
Biological Activity:
Mitoxantrone Hydrochloride (NSC301739; Immunex) is a hydrochloride salt of mitoxantrone which is a synthetic antineoplastic anthracenedione (IC50 = 0.42 mM).Mitoxantrone Hydrochloride (NSC301739; Immunex) is also a synthetic antineoplastic anthracenedione. Mitoxantrone Hydrochloride (NSC301739; Immunex) is a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone Hydrochloride (NSC301739; Immunex) also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. Mitoxantrone Hydrochloride (NSC301739; Immunex) has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity. [1][2]

参考文献

• Desai PB et al. Pharm Res. 1992 Feb; 9(2):178-81