2-乙酰氨基丙烯酸甲酯

• 产品号: L10049
• CAS号: 35356-70-8
• 分子式: C6H9NO3
• 分子量: 143.14056
• 纯 度: 99%

产品别名

• 标题: Methyl 2-acetamidoacrylate
• IUPAC标准名: methyl 2-acetamidoprop-2-enoate
• IUPAC传统名: methyl 2-acetamidoprop-2-enoate
• 别名: Ac-DL-Dha-OMe; 2-Acetamidoacrylic acid methyl ester

产品登记号

• Beilstein号: 1812208
• MDL号: MFCD00013394
• CAS号: 35356-70-8

产品性质

• 纯度: 99%
• 沸点: 103-104°C/8mm
• 熔点: 49-51°C
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 危险公开号: 36/37/38
• 安全公开号: 26-37
• TSCA收录: 否

参考文献

• Building block for amino acid synthesis.
• Heck coupling with 4-iodo-3,5-dimethylphenyl acetate, promoted by palladium acetate and Tri(o-tolyl)phosphine, A12093, is one of the key steps in a convenient asymmetric synthesis of the unnatural amino acid 2,6-dimethyl-L-tyrosine: Synthesis, 741 (1992).
• Asymmetric catalytic hydrogenation in supercritical carbon dioxide in the presence of a chiral rhodium catalyst gives the N-acetylalanine methyl ester in 99.5% ee: J. Am. Chem. Soc., 117, 8277 (1995).
• Undergoes rhodium-catalyzed addition with potassium organotrifluoroborates to give substituted alanine derivatives: Eur. J. Org. Chem., 69 (2004). In the presence of a Rh-BINAP catalyst, chiral amino acid derivaitives are formed with good ee: Angew. Chem. Int. Ed., 43, 719 (2004).