氯代亚磷酸二乙酯

• 产品号: L09919
• CAS号: 589-57-1
• 分子式: C4H10ClO2P
• 分子量: 156.547761
• 纯 度: 97%

产品别名

• 标题: Diethyl chlorophosphite
• IUPAC标准名: diethyl chlorophosphonite
• IUPAC传统名: ethyl phosphorochloridite
• 别名: Diethyl phosphorochloridite

产品登记号

• MDL号: MFCD00009074
• EC号: 209-652-2
• CAS号: 589-57-1
• Beilstein号: 1098392
• 默克索引号: 143841

产品性质

• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN2920
• 联合国危险货物包装类别(PG): II
• GHS危险声明: H314-H318-H226
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 10-14-34
• 安全公开号: 26-36/37/39-45
• 纯度: 97%
• 沸点: 153-155°C
• 密度: 1.082
• 闪点: 25°C(77°F)
• 折射率: 1.4375

参考文献

• Reacts readily with nucleophiles, e.g. amines, alcohols or organometallic species, with the introduction of a phosphorus substituent. The phosphorylation of OH groups has been brought about by treatment with the reagent followed by oxidation of the P(III) product to P(V) with, e.g. iodine: Synth. Commun., 12, 821 (1982); Synthesis, 572 (1986). The chlorophosphite has the advantage of greater reactivity over one-step phosphorylation reagents, e.g. Diphenyl phosphorochloridate, A13546.
• Reagent for peptide coupling: J. Am. Chem. Soc., 74, 5304, 5309 (1952); see Appendix 6. Also useful, in the presence of TMS-OTf, in glycosidic couplings: Tetrahedron Lett., 33, 6123 (1992).
• In the presence of N-ethyldiisopropylamine, reduces both aryl and alkyl nitro compounds to amines: J. Org. Chem., 63, 393 (1998). The reagent also effects dehydration of aldoximes to nitriles, deoxygenation of N-oxides and sulfoxides, and conversion of epoxides to chlorohydrins can also be effected: J. Org. Chem., 67, 711 (2002).