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Clofibrate

产品号 S1820 公司名称 Selleck Chemicals
CAS号 637-07-0 公司网站 http://www.selleckchem.com
分子式 C12H15ClO3 电 话 (877) 796-6397
分子量 242.6987 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 518

产品价格信息

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产品别名

标题
Clofibrate
IUPAC标准名
ethyl 2-(4-chlorophenoxy)-2-methylpropanoate
IUPAC传统名
clofibrate
别名
Atromid-S

产品登记号

CAS号 637-07-0

产品性质

成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cardiovascular Disease
Biological Activity:
Clofibrate (Atromid-S), a fibric acid derivative used in the treatment of hyperlipoproteinemia type III and severe hypertriglyceridemia. Clofibrate increases the activity of extrahepatic lipoprotein lipase (LL), thereby increasing lipoprotein triglyceride lipolysis. Chylomicrons are degraded, VLDLs are converted to LDLs, and LDLs are converted to HDL. This is accompanied by a slight increase in secretion of lipids into the bile and ultimately the intestine. Clofibrate also inhibits the synthesis and increases the clearance of apolipoprotein B, a carrier molecule for VLDL. [1]

参考文献

  • http://www.drugbank.ca/drugs/DB00636