| Item |
Information |
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Drug Groups
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approved |
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Description
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A centrally acting muscle relaxant. Its mode of action is unknown. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1203) |
| Indication |
Used, along with rest and physical therapy, to treat injuries and other painful muscular conditions. Investigated for use in trigeminal neuralgia (tic douloureux), a neuropathic disorder characterized by severe facial pain. Was investigated as a modulator of histamine release. |
| Pharmacology |
Chlorphenesin is a muscle relaxant. It blocks nerve impulses (or pain sensations) that are sent to the brain. |
| Toxicity |
Symptoms of a chlorphenesin overdose include drowsiness and nausea. |
| Affected Organisms |
| • |
Humans and other mammals |
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| Biotransformation |
Hepatic. 85% of a dose excreted within 24 hours as the glucuronide metabolite. |
| Absorption |
Rapid and complete. |
| Half Life |
2.3-5 hours |
| References |
| • |
Malley A, Baecher L: Inhibition of histamine and SRS-A from monkey lung tissue by chlorophenesin. J Immunol. 1971 Aug;107(2):586-8.
[Pubmed]
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| • |
Kurachi M, Aihara H: Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats. Jpn J Pharmacol. 1984 Sep;36(1):7-13.
[Pubmed]
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| • |
Dalessio DJ: Medical treatment of the major neuralgias. Semin Neurol. 1988 Dec;8(4):286-90.
[Pubmed]
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| External Links |
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