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Amlodipine besylate_分子结构_CAS_111470-99-6)
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Amlodipine besylate

产品号 S1813 公司名称 Selleck Chemicals
CAS号 111470-99-6 公司网站 http://www.selleckchem.com
分子式 C26H31ClN2O8S 电 话 (877) 796-6397
分子量 567.05094 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 44446

产品价格信息

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产品别名

标题
Amlodipine besylate
IUPAC标准名
benzenesulfonic acid 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
IUPAC传统名
amlodipine; benzenesulfonic acid
别名
Istin
Norvasc

产品登记号

CAS号 111470-99-6

产品性质

成盐信息 Besylate
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cardiovascular Disease
Biological Activity:
Amlodipine(Norvasc) is a long-acting calcium channel blocker with an IC50 of 1.9 nM.Amlodipine specifically inhibited bTREK-1 in a concentration-dependent manner with an IC50 of 0.43μM.At concentrations that produced near complete block of bTREK-1, amlodipine inhibited voltage-gated Kv1.4 K+ and T-type Ca2+currents in AZF cells by less than 10%. [1]Amlodipine was twice as potent as nifedipine at inhibiting Ca2+-induced contractions in depolarised rat aorta (IC50 1.9 nM vs. 4.1 nM) but, unlike nifedipine, displayed a very slow onset of action.Amlodipine also inhibited 35 mM KCl-induced contractions of pig coronary artery rings (IC50 = 2.2 x 10-8 M) and human coronary artery rings (IC50 = 2.1 x 10-8 M). [2]Hypertension (HTN) or high blood pressure is a cardiac chronic medical condition in which the systemic arterial blood pressure is elevated.Amlodipine besylate has been used for treating hypertension in Phase III. [3]Amlodipine besylate is originally developed by Pfizer.References on Amlodipine besylate (Norvasc)[1] JPET, 2007, 323:39–48,

参考文献

  • http://www.drugbank.ca/drugs/DB00381