双(2-氧代'-3-噁唑烷基)次磷酰氯

• 产品号: L08775
• CAS号: 68641-49-6
• 分子式: C6H8ClN2O5P
• 分子量: 254.564881
• 纯 度: 97%

产品别名

• 标题: Bis(2-oxo-3-oxazolidinyl)phosphinic chloride
• IUPAC标准名: bis(2-oxo-1,3-oxazolidin-3-yl)phosphinoyl chloride
• IUPAC传统名: bis(2-oxo-1,3-oxazolidin-3-yl)phosphinoyl chloride
• 别名: BOP-Cl

产品登记号

• Beilstein号: 3654596
• MDL号: MFCD00010077
• CAS号: 68641-49-6

产品性质

• 纯度: 97%
• 熔点: ca 195°C dec.
• GHS危险声明: H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• 危险公开号: 34
• RTECS编号: SZ5871000
• 安全公开号: 26-36/37/39-45
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN3261
• 联合国危险货物包装类别(PG): II

参考文献

• Coupling reagent for which the rates of reaction with various nucleophiles are sufficiently different to permit a genuine "one-step" coupling of carboxylic acids with amines: Synthesis, 547 (1980). Particularly suitable for coupling N-alkyl amino acids: J. Org. Chem., 51, 3350 (1986). For discussion of strategies for one-step coupling in synthesis of amides, see: Synthesis, 413 (1984), and of the scope and limitations of the reagent in peptide coupling, see: Int. J. Pept. Prot. Res., 29, 574 (1987); J. Org. Chem., 55, 2895 (1990). See also Appendix 6.
• For use in the direct selective 5'-acylation of nucleosides by carboxylic acids, (without 3'-protection), see: Tetrahedron, 44, 229 (1988). For high yield dehydration of carboxylic acids to anhydrides, see: Synthesis, 616 (1981). Also used in macrolide cyclization: J. Am. Chem. Soc., 104, 6818 (1982), and in formation of acyclic esters: Synth. Commun., 14, 515 (1984).
• The mixed anhydride formed with carboxylic acids adds to imines to give ?-lactams: Synthesis, 63 (1982):
  
• These are also formed in high yield by cyclization of ?-amino acids: Bull. Korean Chem. Soc., 12, 457 (1991).