三氟乙酸

• 产品号: L06374
• CAS号: 76-05-1
• 分子式: C2HF3O2
• 分子量: 114.0233496
• 纯 度: 99%

产品别名

• 标题: Trifluoroacetic acid
• IUPAC标准名: trifluoroacetic acid
• IUPAC传统名: trifluoroacetic acid
• 别名: TFA

产品登记号

• MDL号: MFCD00004169
• EC号: 200-929-3
• 默克索引号: 149681
• Beilstein号: 742035
• CAS号: 76-05-1

产品性质

• 纯度: 99%
• 沸点: 72-73°C
• 密度: 1.480
• 熔点: -15°C
• 折射率: 1.2840
• GHS危险声明: H314-H332-H412
• 欧盟危险性物质标志: X
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• 危险公开号: 20-35-52/53
• RTECS编号: AJ9625000
• 安全公开号: 9-26-27/28-45-61
• 保存注意事项: Hygroscopic
• TSCA收录: 是
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN2699
• 联合国危险货物包装类别(PG): I

参考文献

• Carrying out the Curtius rearrangement of acyl azides in TFA leads directly to the trifluoroacetamide, which can be readily hydrolyzed to the free amine: Synthesis, 38 (1983).
• Strong organic acid, widely used in peptide synthesis to cleave N-Boc and t-butyl ester groups: Helv. Chim. Acta, 46, 870 (1963); see also Org. Synth. Coll., 9, 24, 268 (1998). For peptide reagents, see Appendix 6. For selective cleavage of Boc in the presence of Cbz (Z), using 70% TFA in water, see: Liebigs Ann. Chem., 749, 90 (1971). For selective cleavage of benzyl, benzhydryl and trityl ethers in the presence of ester functions, see: Synthesis, 249 (1983).
• Also catalyzes the cleavage of t-butyl groups from t-butylphenols, by reverse Friedel-Crafts reaction: Tetrahedron, 29, 4003 (1973). Similarly, hindered aryl ketones or aromatic carboxylic acids undergo deacylation: Synthesis, 979 (1985).
• With sodium nitrite, has been used for the cleavage of tosylhydrazones: Synthesis, 207 (1979); for nitrosation of anisole and derivatives, avoiding possible loss of the alkyl group: Acta Chem. Scand., 44, 152 (1990); for diazotization of weakly basic arylamines such as pentafluoroaniline or 3,5-dinitroaniline: Synthesis, 566 (1988); and in the presence of formamide, for deamination of arylamines: J. Chem. Soc., Perkin 1, 873 (1986).
• For use of TFA as a catalyst in the Meerwein-Ponndorf-Verley reduction, see Aluminum isopropoxide, 14007. For use in the modification of the reducing properties of borohydride, see Sodium borohydride, 13432. For use in the ionic hydrogenation, see Triethylsilane, A10320.