您当前所在的位置:首页 > 产品中心 > 产品信息
Isradipine_分子结构_CAS_75695-93-1)
点击图片或这里关闭

Isradipine

产品号 S1662 公司名称 Selleck Chemicals
CAS号 75695-93-1 公司网站 http://www.selleckchem.com
分子式 C19H21N3O5 电 话 (877) 796-6397
分子量 371.38714 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 155

产品价格信息

请登录

产品别名

标题
Isradipine
IUPAC标准名
3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
IUPAC传统名
isradipine
别名
Prescal
Clivoten
Esr
PN-200-110
DynaCirc

产品登记号

CAS号 75695-93-1

产品性质

成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cardiovascular Disease
Biological Activity:
Isradipine(Dynacirc) is a calcium channel blocker with an IC50 of 34±8 μM.It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack. [1] the interactive effects of isradipine and blockers or enhancers of nonselective cation channels (NSCCs) and Na+/Ca2+ exchangers (NCXs). Normal human gingival fibroblast Gin-1 cells were used. The [Ca2+]i was measured with the Ca2+-sensitive fluorescent dye fura-2/AM. Changes in the fluorescence intensity of fura-2 in the cells were recorded with a video-imaging analysis system. Ca2+ antagonists (nifedipine, verapamil, and diltiazem in the concentration range of 1 to 20 μM) other than isradipine also raised the [Ca2+]i. [2] 

参考文献

  • Hattori T et al. Eur J Med Res. 2006 Mar 27;11(3)