Nitazoxanide

• 产品号: S1627
• CAS号: 55981-09-4
• 分子式: C12H9N3O5S
• 分子量: 307.28196
• 保 存: -20°C

产品别名

• 标题: Nitazoxanide
• IUPAC标准名: 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate
• IUPAC传统名: nitazoxanide

产品登记号

• CAS号: 55981-09-4

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Infection
Biological Activity:
Nitazoxanide(Alinia, Annita) is a synthetic nitrothiazolyl-salicylamide derivative and an antiprotozoal agent. (IC50 for canine influenza virus ranges from 0.17 to 0.21 μM) The anti- protozoal activity of nitazoxanide is believed to be due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme dependent electron transfer reaction which is essential to anaerobic energy metabolism. [1] It has also been shown to have activity against influenza A virus. Nitazoxanide and tizoxanide inhibited virus replication of all canine influenza virus with 50% and 90% inhibitory concentrations ranging from 0.17 to 0.21 μM and from 0.60 to 0.76 μM, respectively. [2]