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Methimazole

产品号 S1609 公司名称 Selleck Chemicals
CAS号 60-56-0 公司网站 http://www.selleckchem.com
分子式 C4H6N2S 电 话 (877) 796-6397
分子量 114.16884 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 643

产品价格信息

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产品别名

标题
Methimazole
IUPAC标准名
1-methyl-2,3-dihydro-1H-imidazole-2-thione
IUPAC传统名
methimazole
别名
Thiamazole
Metazolo
Basolan

产品登记号

CAS号 60-56-0

产品性质

成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Endocrinology
Biological Activity:
Methimazole(Tapazole, Northyx) is an antithyroid medicine. Methimazole is used to treat hyperthyroidism, a condition where the thyroid gland produces too much thyroid hormone. It is also used before thyroid surgery or radioactive iodine treatment. [1] Methimazole inhibits the addition of iodine to thyroglobulin by the enzyme thyroperoxidase, a necessary step in the synthesis of triiodothyronine(T3) and thyroxine(T4). It does not inhibit the action of the sodium-dependent iodide transporter located on follicular cells’ basolateral membranes. Inhibition of this step requires competitive inhibitors such as perchlorate and thiocyanate. [1]

参考文献

  • http://en.wikipedia.org/wiki/Methimazole