SKF 89976A hydrochloride

• 产品号: S1589
• CAS号: 85375-15-1
• 分子式: C22H26ClNO2
• 分子量: 371.90034
• 保 存: -20°C

产品别名

• 标题: SKF 89976A hydrochloride
• IUPAC标准名: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride
• IUPAC传统名: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride

产品登记号

• CAS号: 85375-15-1

产品性质

• 作用靶点: Angiotensin receptor
• 成盐信息: hydrochloride
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Neurological Disease
Biological Activity:
SKF 89976A is a GABA transporter type 1 inhibitor with IC50 of 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively. It is selective for GAT-1. It inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). Able to pass the blood-brain barrier after systemic administration and is active in vivo. [1]References on SKF 89976A HCl[1] Acta Physiol Scand. , 152(2):173-9, 1994 Oct.

参考文献

• Lewin L et al. Acta Physiol Scand. 1994 Oct;152(2)