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Olmesartan

产品号 S1587 公司名称 Selleck Chemicals
CAS号 144689-63-4 公司网站 http://www.selleckchem.com
分子式 C29H30N6O6 电 话 (877) 796-6397
分子量 558.5851 传 真 (832) 582-8590
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保 存 -20°C Chembase数据库ID: 160

产品价格信息

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产品别名

标题
Olmesartan
IUPAC标准名
(5-methyl-2-oxo-2H-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-({4-[2-(1H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylate
IUPAC传统名
@olmesartan
别名
Benicar
Olmetec

产品登记号

CAS号 144689-63-4

产品性质

作用靶点 Angiotensin receptor
成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cardiovascular Disease
Biological Activity:
Olmesartan is an angiotensin II receptor antagonist with an IC50 of 7.7 nM. It is used to treat high blood pressure. Olmesartan works by blocking the binding of angiotensin II to the AT1 receptors in vascular muscle; it is therefore independent of angiotensin II synthesis pathways, unlike ACE inhibitors. By blocking binding rather than synthesis of angiotensin II, olmesartan inhibits the negative regulatory feedback on renin secretion. As a result of this blockage, olmesartan reduces vasoconstriction and the secretion of aldosterone. This lowers blood pressure by producing vasodilation, and decreasing peripheral resistance. [1]

参考文献

  • http://en.wikipedia.org/wiki/Olmesartan