Cyclosporine

• 产品号: S1514
• CAS号: 79217-60-0
• 分子式: C62H111N11O12
• 分子量: 1202.61124
• 保 存: -20°C

产品别名

• 标题: Cyclosporine
• IUPAC标准名: 30-ethyl-33-[(1R,2R,4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-bis(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontan-2,5,8,11,14,17,20,23,26,29,32-undecone
• IUPAC传统名: cyclosporine
• 别名: Neoral; Gengraf; Restasis; Sandimmune

产品登记号

• CAS号: 79217-60-0

产品性质

• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Immunology
Biological Activity:
Cyclosporine (Neoral) is an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient’s immune system, and therefore the risk of organ rejection. Cyclosporine is thought to bind to the cytosolic protein cyclophilin (immunophilin) of immunocompetent lymphocytes, especially T-lymphocytes. This complex of cyclosporine and cyclophilin inhibits calcineurin, which, under normal circumstances, is responsible for activating the transcription of interleukin 2.