Pirarubicin

• 产品号: S1393
• CAS号: 72496-41-4
• 分子式: C32H37NO12
• 分子量: 627.63568
• 保 存: -20°C

产品别名

• 标题: Pirarubicin
• IUPAC标准名: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione
• IUPAC传统名: (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-6-methyl-5-(oxan-2-yloxy)oxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione
• 别名: THP-Adriamycin

产品登记号

• CAS号: 72496-41-4

产品性质

• 作用靶点: topoisomerase
• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cancer
Biological Activity:
Pirarubicin is an anthracycline drug. An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. [1,2]References on Pirarubicin[1] http://www.cancer.gov/drugdictionary/?CdrID=38775, , [2] http://en.wikipedia.org/wiki/Pirarubicin, ,

参考文献

• http://en.wikipedia.org/wiki/Pirarubicin