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Mizoribine

产品号 S1384 公司名称 Selleck Chemicals
CAS号 50924-49-7 公司网站 http://www.selleckchem.com
分子式 C9H13N3O6 电 话 (877) 796-6397
分子量 259.21602 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 72651

产品价格信息

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产品别名

标题
Mizoribine
IUPAC标准名
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxy-1H-imidazole-4-carboxamide
IUPAC传统名
bredinin
别名
Bredinin

产品登记号

CAS号 50924-49-7

产品性质

作用靶点 DNA/RNA synthesis
成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Immunology
Biological Activity:
Mizoribine (Bredinin) is an imidazole nucleoside and an immunosuppressive agent with an IC50 of approximately 100 μM. The immunosuppressive effect of mizoribine (Bredinin) has been reported to be due to the inhibition of DNA synthesis in the S phase of the cell cycle. Because of its relative lack of toxicity, during the past decade mizoribine (Bredinin) has been frequently used instead of azathioprine as a component of immunosuppressive drug regimens. Mizoribine (Bredinin) is being used to treat renal transplantation patients, IgA nephropathy, lupus erythematosus, and childhood nephrotic syndrome (NS), and some recent studies have assessed the efficacy of oral mizoribine (Bredinin) pulse therapy for severe lupus nephritis, steroid-resistant NS, and frequently relapsing-steroid-dependent NS. [1][2][3]

参考文献

  • http://en.wikipedia.org/wiki/Mizoribine