Cerubidine

• 产品号: S1216
• CAS号: 23541-50-6
• 分子式: C27H30ClNO10
• 分子量: 563.9808
• 保 存: -20°C

产品别名

• 标题: Cerubidine
• IUPAC标准名: (8S,10S)-8-acetyl-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione hydrochloride
• IUPAC传统名: daunorubicin hydrochloride
• 别名: Daunorubicin; Rubidomycin hydrochloride

产品登记号

• CAS号: 23541-50-6

产品性质

• 作用靶点: Topoisomerase
• 成盐信息: HCL
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Biological Activity:
Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is the hydrochloride salt of an anthracycline cytotoxic antibiotic produced by a strain of Streptomyces coeruleorubidus (IC50=0.5μM). On binding to DNA, daunomycin intercalates, with its daunosamine residue directed toward the minor groove. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) has the highest preference for two adjacent G/C base pairs flanked on the 5’ side by an A/T base pair. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) effectively binds to every 3 base pairs and induces a local unwinding angle of 11o, but negligible distortion of helical conformation. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer. Cerubidine (Daunorubicin HCl, Rubidomycin HCl) is most commonly used to treat specific types of leukaemia (acute myeloid leukemia and acute lymphocytic leukemia). Cerubidine (Daunorubicin HCl, Rubidomycin HCl) was initially isolated from Streptomyces peucetius. [1][2][3]

参考文献

• http://www.cancer.gov/drugdictionary/?CdrID=39779