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LY 2886721

产品号 S2156 公司名称 Selleck Chemicals
CAS号 1262036-50-9 公司网站 http://www.selleckchem.com
分子式 C18H16F2N4O2S 电 话 (877) 796-6397
分子量 390.4070464 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 72618

产品价格信息

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产品别名

标题
LY 2886721
IUPAC标准名
N-{3-[(4aS,7aS)-2-amino-4H,4aH,5H,7H,7aH-furo[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide
IUPAC传统名
N-{3-[(4aS,7aS)-2-amino-4H,4aH,5H,7H-furo[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl}-5-fluoropyridine-2-carboxamide
别名
LY2886721

产品登记号

CAS号 1262036-50-9

产品性质

成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area
Description Neurological Disease
Biological Activity
Description LY2886721 is an BACE inhibitor used for the treatment of Alzheimer’s Disease.
Targets BACE γ-secretase
IC50
In Vitro LY2886721 is an oral, small molecule of ?-site amyloid protein cleaving enzyme (BACE) inhibitor with the potential to inhibit the synthesis of ?-amyloid and thereby to slow the clinical progression of AD. [1] LY2886721 can also targetγ-secretase to nhibit the synthesis of ?-amyloid. [2]
In Vivo
Clinical Trials LY2886721 is currently in a Phase II clinical trial in patients with Mild Cognitive Impairment.
Features
References
[1] Adru studies, 2012
[2] Townsend M, et al. J Alzheimers Dis, 2011, 24 Suppl 2, 43-52.