Asenapine maleate

• 产品号: S1283
• CAS号: 85650-56-2
• 分子式: C21H20ClNO5
• 分子量: 401.8402
• 保 存: -20°C

产品别名

• 标题: Asenapine maleate
• IUPAC标准名: (2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(14),7(12),8,10,15,17-hexaene; (2Z)-but-2-enedioic acid
• IUPAC传统名: (2S,6S)-9-chloro-4-methyl-13-oxa-4-azatetracyclo[12.4.0.0^{2,6}.0^{7,12}]octadeca-1(14),7(12),8,10,15,17-hexaene; maleic acid
• 别名: Saphris

产品登记号

• CAS号: 85650-56-2

产品性质

• 作用靶点: 5-HT
• 作用靶点: adrenergic receptor
• 作用靶点: Dopamine Receptor
• 成盐信息: maleate
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Neurological Disease
Biological Activity:
Asenapine is a new atypical antipsychotic developed for the treatment of schizophrenia and acute mania associated with bipolar disorder.Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8), 5-HT2C (10.5), 5-HT5A (8.8), 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. Asenapine behaves as an antagonist at all receptors. [1]

参考文献

• http://www.rxlist.com/saphris-drug.htm