Ramelteon(TAK-375)

• 产品号: S1259
• CAS号: 196597-26-9
• 分子式: C16H21NO2
• 分子量: 259.34344
• 保 存: -20°C

产品别名

• 标题: Ramelteon(TAK-375)
• IUPAC标准名: N-{2-[(8S)-1H,2H,6H,7H,8H-indeno[5,4-b]furan-8-yl]ethyl}propanamide
• IUPAC传统名: rozerem
• 别名: Rozerem; TAK-375

产品登记号

• CAS号: 196597-26-9

产品性质

• 作用靶点: MT
• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Cancer
Biological Activity:
Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT1 (IC50 =28.5 ± 8.55 pM)and MT2 (20.1 ± 9.25 pM)receptors and selectivity over the MT3 receptor. [1]The activity of ramelteon at the MT1 and MT2 receptors is believed to contribute to its sleep-promoting properties. Ramelteon has no appreciable affinity for the GABA receptor complex or for receptors that bind neuropeptides, cytokines, serotonin, dopamine, noradrenaline, acetylcholine, and opiates. [2]

参考文献

• http://en.wikipedia.org/wiki/Ramelteon