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Evista(Raloxifene Hydrochloride

产品号 S1227 公司名称 Selleck Chemicals
CAS号 82640-04-8 公司网站 http://www.selleckchem.com
分子式 C28H28ClNO4S 电 话 (877) 796-6397
分子量 510.04422 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 72582

产品价格信息

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产品别名

标题
Evista(Raloxifene Hydrochloride
IUPAC标准名
2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol hydrochloride
IUPAC传统名
2-(4-hydroxyphenyl)-3-{4-[2-(piperidin-1-yl)ethoxy]benzoyl}-1-benzothiophen-6-ol hydrochloride
别名
Raloxifene Hydrochloride
keoxifene

产品登记号

CAS号 82640-04-8

产品性质

作用靶点 estrogen receptor
成盐信息 Hydrochloride
溶解度 DMSO
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Cancer
Biological Activity:
Raloxifene has estrogen and tamoxifen-like effects on bone and serum cholesterol levels in ovariectomized rats. At 5 weeks, ovariectomy induced a 9% and 18% decrease in the bone mineral density of the lumbar vertebrae L1-4 and proximal tibiae, respectively. Raloxifene prevented this loss of bone with EC50=0.3 mg/kg/day for both the axial and appendicular skeleton. [1]Raloxifene, which demonstrated an extremely low IC50 value of 2.9 nM for phthalazine oxidase in human liver cytosol. [2]References on Evista(Raloxifene HCl)[] DMD, 2004, 32:89–97

参考文献

  • Masahiko Sato et al. J Bone Miner Met. 1994