Finasteride

• 产品号: S1197
• CAS号: 98319-26-7
• 分子式: C23H36N2O2
• 分子量: 372.54414
• 保 存: -20°C

产品别名

• 标题: Finasteride
• IUPAC标准名: (1S,2R,7R,10S,11S,14S,15S)-N-tert-butyl-2,15-dimethyl-5-oxo-6-azatetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-3-ene-14-carboxamide
• IUPAC传统名: finasteride
• 别名: Proscar; Propecia

产品登记号

• CAS号: 98319-26-7

产品性质

• 作用靶点: 5α-reductase
• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Prostate cancer
Biological Activity:
Finasteride, a synthetic 4-azasteroid antiandrogen compound, is a specific inhibitor of steroid Type II 5α-reductase, an intracellular enzyme that converts the androgen testosterone into 5α-dihydrotestosterone (DHT). [1]Finasteride is used in the treatment of prostate cancer, benign prostatic hyperplasia, and androgenetic alopecia (male pattern baldness). [1]In benign prostatic hyperplasia, finasteride inhibits 5alpha-reductase activity in epithelium for Ki of 10nM, significantly lower than in stroma (Ki = 33nM). [2]References on Finasteride[] J. Steroid Biochem. Molec. Biol., 1998, 67:49-55

参考文献

• http://en.wikipedia.org/wiki/Finasteride