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Fulvestrant

产品号 S1191 公司名称 Selleck Chemicals
CAS号 129453-61-8 公司网站 http://www.selleckchem.com
分子式 C32H47F5O3S 电 话 (877) 796-6397
分子量 606.770796 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 823

产品价格信息

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产品别名

标题
Fulvestrant
IUPAC标准名
(1S,9R,10R,11S,14S,15S)-15-methyl-9-[9-(4,4,5,5,5-pentafluoropentanesulfinyl)nonyl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
IUPAC传统名
(1S,9R,10R,11S,14S,15S)-15-methyl-9-[9-(4,4,5,5,5-pentafluoropentanesulfinyl)nonyl]tetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2,4,6-triene-5,14-diol
别名
Faslodex
ICI 182780

产品登记号

CAS号 129453-61-8

产品性质

作用靶点 estrogen receptor
成盐信息 Free Base
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Breast cancer
Biological Activity:
Fulvestrant (Faslodex) is a synthetic estrogen receptor antagonist or selective estrogen receptor down-regulator (SERD). Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. [1] Fulvestrant is used for the treatment of hormone receptor positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. [2]

参考文献

  • http://en.wikipedia.org/wiki/Fulvestrant