Ritonavir

• 产品号: S1185
• CAS号: 155213-67-5
• 分子式: C37H48N6O5S2
• 分子量: 720.94422
• 保 存: -20°C

产品别名

• 标题: Ritonavir
• IUPAC标准名: 1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
• IUPAC传统名: ritonavir
• 别名: Norvir; Norvir Softgel

产品登记号

• CAS号: 155213-67-5

产品性质

• 作用靶点: HIV protease
• 成盐信息: Free Base
• 保存条件: -20°C

产品详细信息

详细说明 (English)

Research Area: Immunology
Biological Activity:
Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS. It is now rarely used for its own antiviral activity, but remains widely used as a booster of other protease inhibitors. More specifically, ritonavir is used to inhibit a particular liver enzyme that normally metabolizes protease inhibitors, cytochrome P450-3A4 (CYP3A4). The drug’s molecular structure inhibits CYP3A4, so a low dose can be used to enhance other protease inhibitors. This discovery has drastically reduced the adverse effects and improved the efficacy of PI’s and HAART. [1]

参考文献

• http://en.wikipedia.org/wiki/Ritonavir