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Docetaxel

产品号 S1148 公司名称 Selleck Chemicals
CAS号 114977-28-5 公司网站 http://www.selleckchem.com
分子式 C43H53NO14 电 话 (877) 796-6397
分子量 807.87922 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 72544

产品价格信息

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产品别名

标题
Docetaxel
IUPAC标准名
(1S,2S,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-{[(tert-butoxy)carbonyl]amino}-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate
IUPAC传统名
(1S,2S,4S,7R,9S,10S,12R,15S)-4-(acetyloxy)-15-{[(2R,3S)-3-[(tert-butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoyl]oxy}-1,9,12-trihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.0^{3,10}.0^{4,7}]heptadec-13-en-2-yl benzoate
别名
Taxotere

产品登记号

CAS号 114977-28-5

产品性质

作用靶点 Microtubule Formation
成盐信息 Free Base
溶解度 DMSO
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area: Solid tumours
Biological Activity:
Docetaxel (Taxotere) is a semi-synthetic, second-generation taxane, with anti-neoplastic application for the treatment of breast, ovarian, and non-small cell lung cancer. [1]Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. The overall cells mean IC50 for docetaxel treatment was 4.67 nM,similar to IC50 values observed across the NCI60 panel of human tumor cell lines, which exhibit a mean docetaxel IC50 of 23.4 nM, with a range of 0.31–100 nM. [2]This agent also inhibits pro-angiogenic factors such as VEGF and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. Docetaxel has been studied for use as a radiation-sensitizing agent. [3] 

参考文献

  • James W. Watters et al. PNAS.2004 August 10;101(32):11809-11814