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ABT-888

产品号 S1004 公司名称 Selleck Chemicals
CAS号 912444-00-9 公司网站 http://www.selleckchem.com
分子式 C13H16N4O 电 话 (877) 796-6397
分子量 244.29234 传 真 (832) 582-8590
纯 度 电子邮件 sales@selleckchem.com
保 存 -20°C Chembase数据库ID: 4883

产品价格信息

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产品别名

标题
ABT-888
IUPAC标准名
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide
IUPAC传统名
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-4-carboxamide
别名
Veliparib

产品登记号

CAS号 912444-00-9

产品性质

作用靶点 PARP
成盐信息 Free Base
溶解度 DMSO
保存条件 -20°C

产品详细信息

详细说明 (English)
Research Area
Description Cancer
Protocol
Kinase Assay [1]
In vitro PARP assays PARP assays are conducted in a buffer containing 50 mM Tris (pH 8.0), 1 mM DTT, 1.5 μM [3H]NAD+ (1.6 μCi/mmol), 200 nM biotinylated histone H1, 200 nM slDNA, and 1 nM PARP-1 or 4 nM PARP-2 enzyme. Reactions are terminated with 1.5 mM benzamide, transferred to streptavidin Flash plates, and counted using a TopCount microplate scintillation counter.
Animal Study [1]
Animal Models NCI-H460, H460, B16F10 and 9L xenografts in C57BL/6 mice
Formulation Formulated in solution containing 0.9% NaCl adjusted to pH 4.0
Doses ~25 mg/kg
Administration Orally administered
References
[1] Donawho CK, et al, Clin Cancer Res, 2007, 13 (9), 2728-2737.
[2] Penning TD, et al, J Med Chem, 2009, 52(2), 514-523.
[3] Albert JM, et al, Clin Cancer Res, 2007, 13(10), 3033-3042.
[4] Kinders RJ, et al, Clin Cancer Res, 2008, 14(21), 6877-6885.
[5] Kinders RJ, et al, Clin Cancer Res, 2008, 14(21), 6877-6885.
[6] Horton TM, et al. 2007 ASCO Annual Meeting, Abstract 9528.
[7] Liu X, et al. Mol Cancer Res, 2009, 7(10), 1686-1692.
[8] Palma JP, et al. Clin Cancer Res, 2009, 15(23), 7277-7290.
[9] Horton TM, et al. ASCO Annual Meeting, 2007, Abs 9528.
[10] Clark CC, et al. Mol Cancer Ther, 2012 Jul 9.