2-(溴甲基)萘

• 产品号: B24568
• CAS号: 939-26-4
• 分子式: C11H9Br
• 分子量: 221.09316
• 纯 度: 96%

产品别名

• 标题: 2-(Bromomethyl)naphthalene
• IUPAC标准名: 2-(bromomethyl)naphthalene
• IUPAC传统名: (2-naphthyl)bromomethane
• 别名: 2-Naphthylmethyl bromide

产品登记号

• Beilstein号: 636546
• CAS号: 939-26-4
• EC号: 213-359-5
• MDL号: MFCD00004123

产品性质

• 纯度: 96%
• 沸点: 213°C/100mm
• 闪点: >110°C(230°F)
• 熔点: 51-55°C
• GHS危险声明: H314-H318
• 欧盟危险性物质标志: 腐蚀性(Corrosive) (C)
• GHS警示性声明: P260-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501A
• 危险公开号: 34
• 安全公开号: 20-26-36/37/39-45
• TSCA收录: 否
• 联合国危险货物等级: 8
• 联合国危险货物编号: UN3261
• 联合国危险货物包装类别(PG): II

参考文献

• Primary or secondary OH groups can be protected as 2-naphthylmethyl (NAP) ethers, e.g. with NaH in DMF. The NAP ether is stable to dilute aqueous HCl or NaOH, but is cleanly hydrogenolyzed with Pd/C; preferential cleavage in the presence of a benzyl ether can be achieved in high yield: J. Org. Chem., 63, 4172 (1998). NAP protection has been utilized in carbohydrate synthesis where stability to 4% TFA in CHCl₃, hot 80% AcOH, SnCl₂/AgOTf, or HCl/EtOH were demonstrated, conditions under which the 4-methoxybenzyl (PMB) group is cleaved; both NAP and PMB groups are efficiently cleaved with DDQ: Tetrahedron Lett., 41, 169 (2000).
• NAP protection of amino groups and other N functions has also been reported. Cleavage was effected under mild condtions with DDQ: Synlett, 2065 (2003).