1,2,3,4-四氢咔唑

• 产品号: B23657
• CAS号: 942-01-8
• 分子式: C12H13N
• 分子量: 171.23832
• 纯 度: 99%

产品别名

• 标题: 1,2,3,4-Tetrahydrocarbazole
• IUPAC标准名: 2,3,4,9-tetrahydro-1H-carbazole
• IUPAC传统名: 2,3,4,9-tetrahydro-1H-carbazole

产品登记号

• EC号: 213-385-7
• MDL号: MFCD00004959
• Beilstein号: 133771
• CAS号: 942-01-8

产品性质

• 纯度: 99%
• 沸点: 325-330°C
• 熔点: 118-120°C
• GHS危险声明: H315-H319-H335-H303
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305+P351+P338-P302+P352-P321-P405-P501A
• 危险公开号: 36/37/38
• RTECS编号: FE6300000
• 安全公开号: 26-37
• TSCA收录: 否

参考文献

• Deprotonation with excess superbasic n-BuLi/KO-t-Bu to give the N,ɑ-dianion has been studied in a variety of ether solvents. Formation of substantial amounts of the ɑ-ethyl derivative was observed with Et₂O and THF, and also, remarkably, with various alkyl methyl ethers; e.g. in n-BuOMe, the ɑ-ethyl product was obtained in 60% yield. The ethyl group originates from the interaction of the solvent with the strong base, confirmed by the detection of ethylene in the absence of the tetrahydrocarbazole substrate: J. Org. Chem., 60, 8334 (1995). ɑ-Ethylation also occurred with 2-ethylindole, but not with 2-methyl- or 2-isopropyl analogues.
• Photooxygenation with singlet oxygen, followed by reduction of the expected hydroperoxide to the allylic alcohol, is accompanied by ring contraction to a spiro ketone. The same product is formed in high yield on treatment of the spiroketone with mineral acid: J. Org. Chem., 61, 810 (1996):