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Dobutamine

产品号 DB00841 公司名称 DrugBank
CAS号 34368-04-2 公司网站 http://www.ualberta.ca/
分子式 C18H23NO3 电 话 (780) 492-3111
分子量 301.38012 传 真
纯 度 电子邮件 david.wishart@ualberta.ca
保 存 Chembase数据库ID: 719

产品价格信息

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产品别名

标题
Dobutamine
IUPAC标准名
4-(2-{[4-(4-hydroxyphenyl)butan-2-yl]amino}ethyl)benzene-1,2-diol
IUPAC传统名
dobutamine
商标名
Racemic-Dobutamine
Dobutrex
Dobutamine Hcl in Dextrose 5%
Dobutamine Hcl
Dobutaminum [INN-Latin]
Dobutamina [INN-Spanish]
Dobutamine Hydrochloride
Dobutamine [Usan:Ban:Inn]
Dobutamine [Usan]
Inotrex

产品登记号

CAS号 34368-04-2
PubChem SID 46505241
PubChem CID 36811

产品性质

疏水性(logP) 3.6

产品详细信息

详细说明 (English)
Item Information
Drug Groups approved
Description A beta-2 agonist catecholamine that has cardiac stimulant action without evoking vasoconstriction or tachycardia. It is proposed as a cardiotonic after myocardial infarction or open heart surgery. [PubChem]
Indication For inotropic support in the short- term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures
Pharmacology Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the beta-adrenoceptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Dobutamine acts primarily on beta-1 adrenergic receptors, with little effect on beta-2 or alpha receptors. It does not cause the release of endogenous norepinephrine, as does dopamine. Dobutamine is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures.
Affected Organisms
Humans and other mammals
Half Life 2 minutes
Elimination In human urine, the major excretion products are the conjugates of dobutamine and 3-O-methyl dobutamine.
External Links
Wikipedia
RxList
Drugs.com

参考文献