(三氟甲基)三甲基硅烷

• 产品号: B20347
• CAS号: 81290-20-2
• 分子式: C4H9F3Si
• 分子量: 142.1949696
• 纯 度: 98%

产品别名

• 标题: (Trifluoromethyl)trimethylsilane
• IUPAC标准名: trimethyl(trifluoromethyl)silane
• IUPAC传统名: trifluoromethyltrimethylsilane
• 别名: Ruppert's Reagent; TFMTMS

产品登记号

• MDL号: MFCD00145454
• EC号: 000-000-0
• CAS号: 81290-20-2
• Beilstein号: 4241868

产品性质

• 纯度: 98%
• 沸点: 54-55°C
• 密度: 0.962
• 闪点: -10°C(14°F)
• 折射率: 1.3305
• GHS危险声明: H225-H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 欧盟危险性物质标志: 易燃性(Flammable) (F)
• GHS警示性声明: P210-P241-P303+P361+P353-P305+P351+P338-P405-P501A
• 危险公开号: 11-36/37/38
• 安全公开号: 9-16-23-26-33-37
• 保存注意事项: Moisture Sensitive
• TSCA收录: 否
• 联合国危险货物等级: 3
• 联合国危险货物编号: UN1993
• 联合国危险货物包装类别(PG): II

参考文献

• Valuable reagent for trifluoromethylation of electrophilic substrates.
• In the presence of F^-, aldehydes and ketones give, after hydrolysis of the intermediate silyl ethers, the trifluoromethyl carbinols: J. Am. Chem. Soc., 111, 393 (1989); J. Org. Chem., 56, 984 (1991); Org. Synth. Coll., 9, 711 (1998):
  
• Alternatively, rapid and efficient trifluoromethylation of carbonyl compounds can be carried out at room temperature in DMSO, in the presence of molecular sieves, without fluoride or other basic catayst: Synlett, 112 (2006). The use of Tri-tert-butylphosphine, 10178 as a catalyst has also been advocated: Synlett, 267 (2006).
• In the presence of CsF and TMS-imidazole, aldimines are converted to ɑ-trifluoromethyl amines: Tetrahedron Lett., 40, 5475 (1999).
• With a catalytic amount of TBAF, excellent yields of trifluoromethyl ketones can be obtained from methyl esters: Angew. Chem. Int. Ed., 37, 820 (1998).
• Similarly, alkyl or aryl thiocyanates are converted to the corresponding trifluoromethyl sulfides in generally good yields: Tetrahedron Lett., 38, 65 (1997). Selenocyanates behave similarly. Trifluoromethylation of aromatics bearing electron-withdrawing groups can be effected in the presence of KF, by displacement of nitro-, cyano- or chloro-substituents: J. Chem. Soc., Perkin 1, 3081 (1998).
• For reviews of this and similar reagents, see: Chem. Rev., 97, 757 (1997); J. Fluorine Chem., 112, 123 (2001).