氯乙酰氯

• 产品号: A15846
• CAS号: 79-04-9
• 分子式: C2H2Cl2O
• 分子量: 112.94268
• 纯 度: 98%

产品别名

• 标题: Chloroacetyl chloride
• IUPAC标准名: 2-chloroacetyl chloride
• IUPAC传统名: chloroacetyl chloride

产品登记号

• CAS号: 79-04-9
• 默克索引号: 142067
• Beilstein号: 605439
• EC号: 201-171-6
• MDL号: MFCD00000725

产品性质

• 纯度: 98%
• 沸点: 105-106°C
• 密度: 1.417
• 熔点: -22°C
• 折射率: 1.4530
• GHS危险声明: H301-H311-H331-H372-H314-H400
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P260-P301+P310-P303+P361+P353-P305+P351+P338-P361-P405-P501A
• 危险公开号: 14-23/24/25-35-48/23-50
• RTECS编号: AO6475000
• 安全公开号: 7/8-9-26-36/37/39-45-61
• 保存注意事项: Moisture Sensitive
• TSCA收录: 是
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: UN1752
• 联合国危险货物包装类别(PG): I

参考文献

• Reagent for the protection of amines as their chloroacetamides. The protecting group can be removed by reaction with thiourea derivatives, forming 2-thiazolidin-4-ones as by-products: J. Am. Chem. Soc., 90, 4508 (1968); Gazz. Chim. Ital., 98, 1261 (1968). Side reactions can be minimized by using 1-Piperidinethiocarboxamide, L12445, as the thiourea: Angew. Chem. Int. Ed., 10, 75 (1971).
• Also used for the protection of alcohols as their chloroacetates: Tetrahedron Lett., 251 (1979). They are hydrolyzed very readily in the presence of many other ester functions: J. Am. Chem. Soc., 86, 118 (194); J. Chem. Soc., Perkin 1, 934 (1975); or can be cleaved with thiourea: Tetrahedron Lett., 251 (1979), ethylenediamine, or mercaptoethylamine: J. Org. Chem., 35, 1940 (1970).