Progabide

• 产品号: DB00837
• CAS号: 62666-20-0
• 分子式: C17H16ClFN2O2
• 分子量: 334.7725432

产品别名

• 标题: Progabide
• IUPAC标准名: 4-{[(4-chlorophenyl)[(1E)-3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene]methyl]amino}butanamide
• IUPAC传统名: gabren
• 商标名: Gabrene; Gabren
• 别名: Halogabide; Progabide [Usan:Ban:Inn]; Progabidum [INN-Latin]; Progabida [INN-Spanish]

产品登记号

• PubChem CID: 5361323
• CAS号: 62666-20-0
• PubChem SID: 46506568

产品性质

• 疏水性(logP): 2.6
• 溶解度: 70.9 mg/L

产品详细信息

详细说明 (English)

• Drug Groups: approved
• Description: Progabide is an analog and prodrug of gamma-aminobutyric acid. It is commonly used in the treatment of epilepsy. It has agonistic activity for both the GABAA and GABAB receptors. Progabide has been investigated for many diseases besides epilepsy, including Parkinson's disease, schizophrenia, clinical depression and anxiety disorder with varying success.
• Indication: Indicated for the treatment of epilepsy.
• Pharmacology: Progabide, a fatty acid derivative, is a GABA receptor agonist used to treat the symptoms of epilepsy.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic
• Absorption: Well absorbed with a bioavailability of 60%
• Half Life: 4 hours
• Protein Binding: 95%
• References: Bartholini G, Scatton B, Zivkovic B, Lloyd KG: GABA receptor agonists and extrapyramidal motor function: therapeutic implications for Parkinson's disease. Adv Neurol. 1987;45:79-83. [Pubmed]
• External Links: Wikipedia

参考文献

• Bartholini G, Scatton B, Zivkovic B, Lloyd KG: GABA receptor agonists and extrapyramidal motor function: therapeutic implications for Parkinson's disease. Adv Neurol. 1987;45:79-83. Pubmed